Antiphospholipid antibody-related clinical manifestations during childhood versus adulthood: descriptive results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) clinical database and repositor
Our analysis of an international registry for persistently aPL-positive patients demonstrates that patients with paediatric-onset aPL-related manifestations more commonly present with non-vascular events. These results highlight the importance of understanding the clinical differences between paediatric and adult APS patients, which have diagnostic, therapeutic, and research implications.
Authors
- Esther Rodríguez-Almaraz (ORCID: https://orcid.org/0000-0003-0839-5644)
- Guilherme Ramires de Jesús (ORCID: https://orcid.org/0000-0002-6715-0180)
- Megan R.W. Barber (ORCID: https://orcid.org/0000-0003-1055-1335)
- Vittorio Pengo (ORCID: https://orcid.org/0000-0003-2064-6071)
- Maria Efthymiou (ORCID: https://orcid.org/0000-0001-9704-2845)
- Nina Kello (ORCID: https://orcid.org/0000-0001-5497-7472)
- Savino Sciascia (ORCID: https://orcid.org/0000-0003-1266-9441)
- Marissa Dale
- Doruk Erkan (ORCID: https://orcid.org/0000-0001-7216-677X)
- Ann E. Clarke (ORCID: https://orcid.org/0000-0002-3112-9646)
- Alí Duarte‐García (ORCID: https://orcid.org/0000-0003-1749-5719)
- María Laura Bertolaccini (ORCID: https://orcid.org/0000-0002-8623-139X)
- Guillermo Pons‐Estel (ORCID: https://orcid.org/0000-0002-0647-929X)
- Hui Shi (ORCID: https://orcid.org/0000-0002-3574-8807)
- D. Paredes (ORCID: https://orcid.org/0000-0001-8378-8638)
- Leslie Skeith (ORCID: https://orcid.org/0000-0002-5587-398X)
- Bahar Artım-Esen (ORCID: https://orcid.org/0000-0002-5659-3955)
- Ricard Cervera (ORCID: https://orcid.org/0000-0001-6085-492X)
- Cecilia Nalli (ORCID: https://orcid.org/0000-0003-2514-9891)
- José Pardos‐Gea (ORCID: https://orcid.org/0000-0002-3725-6849)
- Yu Zuo (ORCID: https://orcid.org/0000-0001-6721-7755)
- Ariadna Anunciación-Llunell (ORCID: https://orcid.org/0000-0002-0468-1232)
- Massimo Radin (ORCID: https://orcid.org/0000-0003-1941-2606)
- María Ángeles Aguirre-Zamorano
- Giulia Pazzola
- H. Michael Belmont (ORCID: https://orcid.org/0000-0003-3389-2976)
- Zhuoli Zhang (ORCID: https://orcid.org/0000-0001-7219-9141)
- Rohan Willis (ORCID: https://orcid.org/0000-0002-1374-7678)
- Hannah Cohen (ORCID: https://orcid.org/0000-0003-2032-390X)
- Jayesh Bhatt (ORCID: https://orcid.org/0000-0003-0083-7460)
- Maria Gerosa (ORCID: https://orcid.org/0000-0001-5241-5847)
- Maria G. Tektonidou (ORCID: https://orcid.org/0000-0003-2238-0975)
- Paul R. Fortin (ORCID: https://orcid.org/0000-0002-7278-2596)
- Tatsuya Atsumi (ORCID: https://orcid.org/0000-0001-5657-962X)
- Danieli Andrade (ORCID: https://orcid.org/0000-0002-0381-1808)
- Denis Wahl
- Michelle Petri
- Ware Branch
Institutions
- Intermountain Healthcare (US)
- Hospital for Special Surgery (US)
- Northwell Health (US)
- University of Padua (IT)
- Johns Hopkins University (US)
- Inserm (FR)
- University of Calgary (CA)
- Universidade de São Paulo (BR)
- Shanghai Jiao Tong University (CN)
- King's College London (GB)
- University of Milan (IT)
- National and Kapodistrian University of Athens (GR)
- Peking University (CN)
- Cornell University (US)
- University of Utah (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- Ruijin Hospital (CN)
- Universidade do Estado do Rio de Janeiro (BR)
- NYU Langone Health (US)
- BioCruces Health research Institute (ES)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Hospital Universitario 12 De Octubre (ES)
- AdventHealth for Children (US)
- Hospital Provincial de Rosario (AR)
- Hospital Clínic de Barcelona (ES)
- Hospital Universitario Reina Sofía (ES)
- Mayo Clinic in Arizona (US)
- Vall d'Hebron Hospital Universitari (ES)
- Torino e-district (IT)
- Peking University First Hospital (CN)
- Centre hospitalier de l'Université Laval (CA)
- Hokkaido University Hospital (JP)
- Université Laval (CA)
- Défaillance Cardiovasculaire Aiguë et Chronique
- University College London (GB)
- University of Turin (IT)
- The University of Texas Medical Branch at Galveston (US)
- Istanbul University (TR)
- University of Brescia (IT)
- Université de Lorraine (FR)
Publication Details
- Journal
- Clinical and Experimental Rheumatology
- Published
- 2025-03-23
- DOI
- https://doi.org/10.55563/clinexprheumatol/t46qkf
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00