Effects of low-intensity endurance exercise and low-dose lithium chloride administration on muscle atrophy in high-fat diet induced obese rats

A combination of low-intensity endurance exercise and low-dose lithium prevented muscle atrophy (wasting) by inhibiting the FOXO1 signaling pathway in skeletal muscles. Therefore, light walking and lithium supplementation in daily life are expected to prevent muscle atrophy in obese patients. However, it is difficult to draw definitive conclusions based on the results of this study alone and additional research is warranted.