Diastereoselective construction of structurally diverse polycyclic spiroindolenines <i>via</i> Yb(OTf) <sub>3</sub> -catalyzed cascade [1,5]-hydride transfer/cyclization
A Lewis-acid-catalyzed redox neutral cascade [1,5]-hydride transfer/cyclization between indolin-2-imines and 2-amino-substituted benzaldehydes has been disclosed. A series of novel, pharmaceutically interesting polycyclic spiroindolenines containing tetrahydroquinolines was obtained in good to excellent yields with excellent diastereoselectivity.
Authors
- Song Hu (ORCID: https://orcid.org/0000-0002-5760-8012)
- Dan Hu (ORCID: https://orcid.org/0000-0001-5860-3849)
- Chen‐Yi Li (ORCID: https://orcid.org/0009-0008-8344-215X)
- Yulong Li (ORCID: https://orcid.org/0000-0002-5579-3269)
- Ying Xie (ORCID: https://orcid.org/0000-0002-0237-3244)
- Jian Wang (ORCID: https://orcid.org/0000-0003-0806-9590)
- Heng Yin (ORCID: https://orcid.org/0000-0001-6553-0887)
- Jianming Xu
Institutions
- Nankai University (CN)
- Chemical Synthesis Lab (SG)
- Sichuan University of Science and Engineering (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01005e
- Citations
- 2
- Primary Topic
- Synthesis and pharmacology of benzodiazepine derivatives
- Type
- article
- Field-Weighted Citation Impact
- 1.87