Design, Synthesis and Biological Evaluation of Novel Heterocyclic Chalcones Derivatives of 2,4-Thiazolidine Dione as Anti-Cancer Agents

A simple and eco-friendly synthesis of thiazolidinedione-based chalcone derivatives using aldehydes and various alkyl/aryl halides in the presence of Triton B as a nonmetallic base was designed and their biological activity was evaluated in the present study. The procedure is applicable for a variety of aryl and alkyl halides, and yields are very good. The use of a nonmetallic nature of the base makes this protocol an ecofriendly alternative. The synthesized compounds were evaluated for their potential anti-cancer activity against a panel of human cancer cell lines including breast cancer (MCF-7, MDA-MB-453), lung cancer (A549), and prostate cancer (PC-3) by MTT assay.