The Ki67-Expressing cells: Hidden gems in the Oral Cavity of adult Mammal

Introduction: Neurogenesis in the mammal exists in several neurogenic areas such as subventricular region, subgranular zone of dentate gyrus of the brain and central canal of the spinal cord. The existence of dividing cells in these areas can be demonstrated with immunohistochemistry marker such as Ki67. It is possible that there is an existence of other proliferative areas such in the oral cavity. Objectives: To identify the Ki67-expressing cells in the spinal cord, and oral region such as tongue. Methodology: Sprague Dawley rats were used, and the tissues from the spinal cord, and tongue were taken and stained using Ki67. The slides were reviewed under light microscope. Results: The tissues from the spinal cord (lamina X of the grey matter), and areas around oral cavity such as tongue were stained positive with Ki67 marker. Conclusion: The Ki67-expressing cells were identified in the oral cavity such as taste buds, thyroglossal duct and ganglion.