Relationship between Testosterone levels in healthy men with Urea, Creatinine, Hemoglobin and Red blood cell properties. A Clinical study in Syria

Introduction: Testosterone is a crucial sex hormone that significantly influences various bodily functions, including fertility, bone density, fat distribution, muscle strength, and red blood cell production. Its levels tend to decline with age. Researchers suggest that testosterone may positively affect conditions such as metabolic syndrome, type 2 diabetes, and cardiovascular risk factors. Purpose: This study aimed to investigate the relationship between testosterone levels and several biological markers, including urea, creatinine, and red blood cell properties (RBC count, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and red cell distribution width (RDW)). Methods: The study involved 100 healthy men aged between 24 and 74 years, excluding those with kidney disease or diabetes. Participants were divided into two age groups: Group 1 (ages 25±2 years) and Group 2 (ages ≥65years). Results: Testosterone levels significantly decreased with age. No correlation was found between testosterone levels and urea. However, lower testosterone concentrations were associated with increased creatinine levels. Additionally, the properties of red blood cells (RBC count, hemoglobin, hematocrit, MCV, MCH, RDW) showed significant reductions at lower testosterone levels. Conclusion: The findings of this study suggest that declining testosterone levels in aging men are associated with adverse changes in kidney function and red blood cell parameters. These results highlight the potential importance of monitoring testosterone levels in older men to better understand its implications for overall health and to inform clinical strategies aimed at mitigating age-related health risks.