Divergent synthesis of 3-formylpyrazolo[1,5- <i>a</i> ]pyrimidines and methylene-bridged bis(pyrazolo[1,5- <i>a</i> ]pyrimidines) using DMSO as a single carbon synthon
A divergent approach has been explored for synthesizing 3-formylpyrazolo[1,5-<i>a</i>]pyrimidines and methylene-bridged bis(pyrazolo[1,5-<i>a</i>]pyrimidines) using DMSO as a C1 synthon. A library of 3-formylpyrazolo[1,5-<i>a</i>]pyrimidines and methylene-bridged bis(pyrazolo[1,5-<i>a</i>]pyrimidines) has been synthesized using CuOAc and AcOH, respectively. The reaction progressed through a radical pathway. The usefulness of 3-formylpyrazolo[1,5-<i>a</i>]pyrimidines in synthesizing a zaleplon derivative has been demonstrated.
Authors
- Papiya Sikdar (ORCID: https://orcid.org/0009-0008-4573-1233)
- Sanghapal D. Sawant (ORCID: https://orcid.org/0000-0002-6224-3214)
- Avik Kumar Bagdi (ORCID: https://orcid.org/0000-0003-3855-1046)
- Sourav Das (ORCID: https://orcid.org/0000-0002-8155-0383)
- Sheetal Saini
Institutions
- National Chemical Laboratory (IN)
- University of Kalyani (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01042j
- Citations
- 3
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Science and Engineering Research Board