Chemical proteomics reveals hesperidin and hesperetin as AKR1C1/2 inhibitors with chemosensitization effect
The natural flavanone hesperidin and its aglycone hesperetin were identified as human aldo-keto reductase family 1 member C1 (AKR1C1) and AKR1C2 inhibitors <i>via</i> chemoproteomic profiling, which provides mechanistic insight into their chemosensitization effects in cancer therapy.
Authors
- Yuanyuan Zhou (ORCID: https://orcid.org/0000-0001-6062-3363)
- Yiyun Geng
- Ran Lu (ORCID: https://orcid.org/0000-0003-0486-532X)
- Zhangshuang Deng (ORCID: https://orcid.org/0000-0001-5929-235X)
- Jingyuan Xu (ORCID: https://orcid.org/0000-0002-6306-6213)
- Hongyue Ma (ORCID: https://orcid.org/0000-0002-0987-8317)
- Lijun Chen (ORCID: https://orcid.org/0000-0002-4685-4533)
- Yiqing Zhou (ORCID: https://orcid.org/0000-0002-6391-3259)
- Jian-Jia Liang (ORCID: https://orcid.org/0009-0004-7097-9899)
Institutions
- China Three Gorges University (CN)
- Suzhou University of Science and Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02907d
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China