Spongiotic psoriasiform dermatitis with dual features of eczema and psoriasis: Janus kinase inhibition as a potential therapeutic option
SD/PSO represents a mixed AD-PSO immunophenotype with PSO-like differentiation patterns, characterized by coactivated Th17/Th2 pathways and JAK-STAT hyperactivation. JAK inhibitors effectively treat patients with SD/PSO by suppressing multi-T-cell axis-targeted inflammatory signals and blocking epidermal hyperproliferation, establishing JAK-STAT inhibition as a targeted strategy. Larger studies are needed to validate results and explore combination therapies.
Authors
- Chaolan Pan (ORCID: https://orcid.org/0000-0003-3378-4676)
- Peiyi Sun
- Yumeng Wang (ORCID: https://orcid.org/0000-0002-5298-3171)
- Qianyue Xu (ORCID: https://orcid.org/0000-0002-9431-411X)
- Jiawen Li
- Xiaoxiao Wang (ORCID: https://orcid.org/0000-0002-4458-9166)
- Chunxiao Li (ORCID: https://orcid.org/0000-0002-5821-0225)
- Zhirong Yao (ORCID: https://orcid.org/0000-0003-1308-6002)
- Wenjie Cheng (ORCID: https://orcid.org/0000-0003-4093-7511)
- Jinxiang Yang (ORCID: https://orcid.org/0009-0007-3733-1996)
- Xuanyi Chen
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
Publication Details
- Journal
- Clinical and Experimental Dermatology
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1093/ced/llaf336
- Citations
- 4
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 8.02