Methodological reflections on systematic reviews: from meta-analysis to the application of the SWiM guideline

Introduction: Cardiovascular diseases are the most important cause of death worldwide.The etiology is multifactorial, they may be influenced by various factors such as diet, lifestyle, level of exercise or genetics.The large number of genes involved, as well as its various forms, can influence the risk of cardiovascular diseases through different forms.Aim: To determine the relationship between different genetic polymorphisms and individual risk of CHD in child and adult population.Methods: A literature search was performed using PubMed database.The search was limited to a period of ten years and meta-analysis performed in humans.Results: The relationship between the risk of cardiovascular disease and the following genetic polymorphisms: chromosome 9p21, apolipoprotein A5, apolipoprotein E2, E3 and E4, gen PPARG or PPAR, genes involved in lipid metabolism, MTHFR gene, cytochrome P450, factor V, coagulation factor Leiden (FVL) and gen VKORC was reviewed.Conclusions: We have identified a number of genes related to cardiovascular disease.The genetic can influence directly or indirectly on cardiovascular risk by modifying risk factors for cardiovascular or acting on the medication used to treat it.