New insights into lipid droplet breakdown in alcohol-associated hepatic steatosis.
The mechanisms by which alcohol increases lipid droplet accumulation are still unclear. In this issue, Sen et al. (https://doi.org/10.1083/jcb.202408205) identify a new pathway through which chronic alcohol exposure promotes hepatic steatosis via a UBXD8-p97/VCP-HSD17β13 axis, which regulates lipid droplet homeostasis.
Authors
- Wen‐Xing Ding (ORCID: https://orcid.org/0000-0002-3167-5073)
- Chen Zhang (ORCID: https://orcid.org/0000-0001-7609-980X)
Institutions
- University of Kansas Medical Center (US)
- Motility (United States) (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1083/jcb.202506103
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health