Minocycline Regulates PARP-1 and HDAC3 Pathways to Inhibit Inflammation and Oxidative Stress in LPS-Induced Acute Lung Injury
In conclusion, our study presents minocycline as a potential candidate for ALI therapy and provides an experimental foundation for investigating its anti-inflammatory mechanisms in the treatment of ALI. Further therapeutic value awaits verification in clinical and preclinical studies.
Authors
- Chao Luo
- Jiefei Liang (ORCID: https://orcid.org/0000-0001-7384-2792)
- Weibin Wu (ORCID: https://orcid.org/0000-0003-4308-0664)
- Guo-Hua Shen
- Chunyan Zhu
- Xixi Zhu (ORCID: https://orcid.org/0009-0001-0384-9339)
Institutions
- Zhaoqing University (CN)
- Shaoxing University (CN)
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-06-29
- DOI
- https://doi.org/10.5812/ijpr-161381
- Citations
- 2
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province