Dearomatization [4+2] cycloaddition for constructing bridged polycyclic lactams
This article presents a metal-free catalytic system for the [4+2] cycloaddition of isoquinoline and maleimide derivatives, enabling the one-step construction of structurally complex bridged polycyclic lactams. This three-component tandem cyclization reaction generates C-N, CO, and C-C bonds, achieving functionalization at the C1, N2, C3, and C4 positions of 3-halogenated isoquinolines. This dearomatization strategy exhibits exceptional chemoselectivity and regioselectivity, operates without transition metals, and offers a high atom and step economy.
Authors
- Zhongzhi Zhu (ORCID: https://orcid.org/0000-0003-1690-9238)
- Tsz Woon Benedict Lo (ORCID: https://orcid.org/0000-0002-4853-0196)
- Xiuwen Chen (ORCID: https://orcid.org/0000-0003-3301-6730)
- Jingyi Chen (ORCID: https://orcid.org/0000-0002-3476-1540)
- Shasha Wang (ORCID: https://orcid.org/0000-0002-2136-6576)
- Jiaxin Liang (ORCID: https://orcid.org/0000-0002-7559-2616)
- Qile Wu
- Haoxian Wu
Institutions
- Hong Kong Polytechnic University (HK)
- Wuyi University (CN)
- Wuyi University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03128a
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Education of Guangdong Province