DETECÇÃO DE FLAVONOIDES COM PROPRIEDADES TRIPANOCIDA E ANTIOXIDANTE NAS FOLHAS DE Senna multijuga (Fabaceae)

DETECTION OF FLAVONOIDS WITH TRYPANOCIDAL AND ANTIOXIDANT PROPERTIES IN THE LEAVES OF Senna multijuga (FABACEAE). Senna multijuga (Fabaceae) is a plant species native from Brazil and it has been used to recover degraded areas. There are a few reports about its chemical composition and biological activities. Therefore, this study aimed to conduct preliminary dereplication studies and evaluate the antioxidant activity by chemical and electrochemical methods of the ethanolic extract of S. multijuga (SM) leaves and its trypanocidal activity. High-performance liquid chromatography-electrospray ionization-ion trap-mass spectrometry (HPLC-ESI-IT-MS) based on molecular networking dereplication of the leaves and branches extracts led to annotation of one caffeoylquinic acid, one flavonol, two flavanones, and seven flavonol glycosides. Some of these metabolites are reported for the first time for this species. The leave extract showed significant radical scavenging properties. On the other hand, SM was more cytotoxic to 3T3 fibroblasts than to Trypanosoma cruzi epimastigotes (selectivity index (SI) = 0.23). Results showed a good agreement between the antioxidant power of extracts and their content of phenolic compounds.