Inhibiting Rac1 signaling alleviates DSS-induced colitis by improving inflammatory response and intestinal permeability
Rac1 inhibitor NSC23766 attenuates symptoms, colonic inflammation, and intestinal permeability in a DSS-induced colitis model. These effects may be attributed to the suppression of inflammatory responses and DSS-induced damage of intestinal integrity.
Authors
- Changhui Yu (ORCID: https://orcid.org/0000-0002-6174-6012)
- Canhua Luo (ORCID: https://orcid.org/0000-0001-5292-8706)
- Miaomiao Ma (ORCID: https://orcid.org/0000-0001-8115-4148)
- Mei-Hong Lin
- Leshi Liang (ORCID: https://orcid.org/0000-0002-6586-8519)
- Xingfeng Deng
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Zhujiang Hospital (CN)
- Huizhou Central People's Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- Gastroenterology report
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/gastro/goaf073
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangdong Province