Prognostication and treatment predictions for estrogen receptor positive early-stage breast cancer: incorporating the 70-gene signature into the PREDICT prognostication model
Extending PREDICT-v2.3 with 70-GS led to modest improvement in its ability to predict 5-year risk of breast cancer death. Future research should focus on assessing the added value of the 70-GS for longer-term prediction of recurrence and death with the incorporation of quality of life in risk prediction tools.
Authors
- Coralie Poncet (ORCID: https://orcid.org/0000-0002-8635-9350)
- Marjanka K. Schmidt (ORCID: https://orcid.org/0000-0002-2228-429X)
- Ellen G. Engelhardt (ORCID: https://orcid.org/0000-0003-0016-4972)
- Laura van ‘t Veer (ORCID: https://orcid.org/0000-0002-9838-8298)
- Emiel J. Rutgers (ORCID: https://orcid.org/0000-0002-4244-0106)
- Fátima Cardoso (ORCID: https://orcid.org/0000-0002-6692-2249)
- Mary Ann E. Binuya (ORCID: https://orcid.org/0000-0001-8682-8690)
- Sabine C. Linn (ORCID: https://orcid.org/0000-0001-5541-0347)
- Martine Piccart (ORCID: https://orcid.org/0000-0001-9068-8504)
- Paul D.P. Pharoah (ORCID: https://orcid.org/0000-0001-8494-732X)
- Ewout W. Steyerberg (ORCID: https://orcid.org/0000-0002-7787-0122)
Institutions
- Champalimaud Foundation (PT)
- Cedars-Sinai Medical Center (US)
- Université Libre de Bruxelles (BE)
- Leiden University Medical Center (NL)
- Institut Jules Bordet (BE)
- The Netherlands Cancer Institute (NL)
- Oncode Institute (NL)
- European Organisation for Research and Treatment of Cancer (BE)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
Publication Details
- Journal
- The Breast
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1016/j.breast.2025.104542
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00