Clinical phenotype of anticoagulant discontinuation and the long-term prognosis in atrial fibrillation patients with high bleeding risk: A report from the GLORIA-AF registry
Being an older patient with frailty and having chronic kidney disease, chronic obstructive pulmonary disease, peripheral arterial disease, multimorbidity, and polypharmacy were risk factors for OAC discontinuation. OAC discontinuation was independently associated with a higher risk of mortality, major bleeding, TE, and MACE in patients with AF at high risk of bleeding.
Authors
- Tommaso Bucci (ORCID: https://orcid.org/0000-0003-2895-6234)
- Menno V. Huisman (ORCID: https://orcid.org/0000-0003-1423-5348)
- Brian Olshansky (ORCID: https://orcid.org/0000-0002-6044-045X)
- Kui Hong
- Steven Ho Man Lam (ORCID: https://orcid.org/0000-0003-2147-0995)
- Manlin Zhao (ORCID: https://orcid.org/0000-0002-5073-1798)
- Giulio Francesco Romiti (ORCID: https://orcid.org/0000-0002-3788-8942)
- Yang Chen (ORCID: https://orcid.org/0009-0008-2782-476X)
- Yang Liu (ORCID: https://orcid.org/0000-0003-4430-3452)
- Gregory Y H Lip
- Tze-Fan Chao
- Hongyu Liu (ORCID: https://orcid.org/0000-0003-0383-8725)
Institutions
- University of Iowa (US)
- Nanchang University (CN)
- University of Liverpool (GB)
- National Yang Ming Chiao Tung University (TW)
- Leiden University Medical Center (NL)
- Taipei Veterans General Hospital (TW)
- Liverpool Heart and Chest Hospital (GB)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Liverpool John Moores University (GB)
Publication Details
- Journal
- Heart Rhythm
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.hrthm.2025.07.034
- Citations
- 1
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Institute for Health and Care Research
- University of Liverpool
- China Scholarship Council
- Horizon 2020 Framework Programme