Case-based evidence links increased SARS-CoV-2 diversity to impaired IFN-I response in severe COVID-19
We present a case of increased within-host viral diversity linked to impaired type I interferon response during COVID-19.
Authors
- François Dhelft (ORCID: https://orcid.org/0000-0002-2920-9831)
- Laurence Generenaz (ORCID: https://orcid.org/0009-0007-6691-631X)
- Sophie Trouillet‐Assant (ORCID: https://orcid.org/0000-0001-6439-4705)
- Maxime Gaillet
- Hadrien Regue (ORCID: https://orcid.org/0000-0002-1312-4649)
- Donatien de Marignan (ORCID: https://orcid.org/0009-0008-8697-7854)
- Auguste Dargent (ORCID: https://orcid.org/0000-0003-1784-1212)
- Inès Noirot
- Antonin Bal (ORCID: https://orcid.org/0000-0002-0261-2495)
- Mehdi Mezidi (ORCID: https://orcid.org/0000-0002-8715-8323)
- David Bussy (ORCID: https://orcid.org/0009-0007-4037-2270)
- Laurence Josset (ORCID: https://orcid.org/0000-0002-7158-1186)
- Louis Chauvelot (ORCID: https://orcid.org/0000-0001-5995-7921)
- Valérie Cheynet (ORCID: https://orcid.org/0000-0001-6168-1821)
- Kylian Trepat (ORCID: https://orcid.org/0000-0003-2960-1515)
- Laurent Bitker (ORCID: https://orcid.org/0000-0002-4698-053X)
- Jean‐Christophe Richard (ORCID: https://orcid.org/0000-0003-1503-3035)
- Florent Wallet (ORCID: https://orcid.org/0000-0003-3174-6246)
- Guillaume Deniel (ORCID: https://orcid.org/0000-0002-4006-6114)
- Hodane Yonis
- Yolanda Cristina Valdés Rodríguez
- Rosalie Schoux
Institutions
- Université Claude Bernard Lyon 1 (FR)
- École Normale Supérieure de Lyon (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Lyon College (US)
- Hôpital de la Croix-Rousse (FR)
- Hospices Civils de Lyon (FR)
- Laboratoire National de Référence (MA)
- Centre International de Recherche en Infectiologie (FR)
- Institut National des Sciences Appliquées de Lyon (FR)
Publication Details
- Journal
- Journal of Human Immunity
- Published
- 2025-07-24
- DOI
- https://doi.org/10.70962/jhi.20250019
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Agence Nationale de la Recherche
- Hospices Civils de Lyon