Efficacy of Combined Plant Extracts in Reducing Inflammation: A Comparative Study

Inflammation is tissue immune response leading to redness, pain, swelling and color change. The secondary metabolites of the plants possess anti-inflammatory potential. NSAIDs class of drugs restore the inflammatory condition but enhance the risk of clotting and ultimately lead to heart attack and stroke. Thus, studies are underway to develop natural anti-inflammatory medicines. A key component of herbal therapies is utilized to reduce inflammation. The present study deals with the screening of anti-inflammatory potential of hydroalcoholic extracts of Albizia lebbeck and Hibiscus rosa sinensis in both in-vitro and in-vivo studies. Combined extracts of Hibiscus rosa sinensis and Albizia lebbeck has shown marked effect than individual extracts. The significant restoration was observed at 300 mg/kg, for both extracts in carrageenan, dextran induced inflammatory condition. Heat induced hemolysis has shown maximum restoration at concentration 200 ug/ml of combined extracts. The present investigation documented the capacity of individual plants and their combination to exhibit synergistic effects. The activity of Albizia lebbeck and Hibiscus rosa sinensis is attributed to the presence of phytochemicals, including flavonoids, steroids, phenolics, and terpenoids. By adhering to the established procedures for evaluating anti-inflammatory properties, such as carrageenan and dextran-induced paw edema and heat-induced hemolysis, the combined extract at doses of 300mg/kg and 200ug/ml respectively demonstrated a significant and notable effect compared to the positive control diclofenac sodium. The current results indicate potential for future in-vivo correlation and the ability to specifically target wound healing activities.