Clinical–Biological Assessment of Prosthetic Field Following Pre-Prosthetic Phase Related to Prosthetic Treatment Solutions

<b>Background</b>. Extensive partial edentulism alters the biological and functional balance of the stomatognathic system, requiring targeted pre-prosthetic procedures to optimize treatment outcomes. <b>Objectives</b>. The aim of this study was to assess the extent of improvement in the clinical-biological scores of the prosthetic field in patients with extensive edentulism, following pre-prosthetic interventions. <b>Materials and Method</b>. This prospective, cross-sectional study investigated 194 subjects with extensive partial edentulism. Clinical-biological scores, initially and following the pre-prosthetic phase, were recorded using a scoring system that evaluated dental and periodontal status, bone and mucosal support, occlusion, and mandibulo-cranial relationships. Statistical comparisons of clinical-biological scores were related to the type of prosthetic therapy. Statistical significance was considered at a <i>p</i>-value < 0.05. <b>Results</b>. There was an overall significant improvement in the clinical-biological scores initially (mean value 20.2) and after pre-prosthetic procedures (mean value 23.22) (<i>p</i> < 0.001). When treatment groups were divided, the implant-assisted prosthesis group showed the best improvement in all domains, followed by the conventional fixed-prostheses group (<i>p</i> < 0.01). Dental support improved significantly in those with semi-rigid composite prostheses (<i>p</i> = 0.014), while periodontal support was improved in both fixed- and hybrid-implant groups. Mucosal and bone support improved mostly in the fixed-implant groups (<i>p</i> = 0.014). <b>Conclusions</b>. Pre-prosthetic procedures significantly enhance the biological and functional readiness of the prosthetic field, with the degree of improvement influenced by the complexity and type of planned prosthetic rehabilitation. The findings underscore the value of individualized pre-prosthetic protocols as an essential component of prosthetic treatment planning.