Executive dysfunction relates to salience network desegregation in behavioural variant frontotemporal dementia
Results demonstrate associations between executive dysfunction and salience network de-differentiation in patients with bvFTD. Our findings indicate that brain network de-differentiation, reflecting reduced neural capacity for specialized processing, may contribute to the emergence of executive dysfunction in bvFTD.
Authors
- James C. Gee (ORCID: https://orcid.org/0000-0002-2258-0187)
- Philip A. Cook (ORCID: https://orcid.org/0000-0002-1985-8475)
- Emma Rhodes (ORCID: https://orcid.org/0000-0002-9053-0114)
- Jeffrey S. Phillips (ORCID: https://orcid.org/0000-0003-0079-9441)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Christopher A. Olm (ORCID: https://orcid.org/0000-0002-4858-2359)
- Melanie A. Matyi (ORCID: https://orcid.org/0000-0002-4623-2080)
- Hamsanandini Radhakrishnan (ORCID: https://orcid.org/0000-0002-4448-986X)
- Lauren Massimo (ORCID: https://orcid.org/0000-0002-3407-7335)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.nicl.2025.103853
- Citations
- 2
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86