Nrf2/STAT3-mediated activation of SLC6A3 underlies the neuroprotective effect of quercetin in ischemic stroke
Our findings identify the Nrf2/STAT3/SLC6A3 axis as a key mediator of quercetin's neuroprotective effects in ischemic stroke. To our knowledge, this is the first study to identify the Nrf2/STAT3/SLC6A3 axis as a key regulatory pathway underlying the neuroprotective action of quercetin.
Authors
- Wan-Yan Xu (ORCID: https://orcid.org/0009-0005-2871-6347)
- Tian-Hang Yu
- Wen-Bao Mao
- J. Wang (ORCID: https://orcid.org/0000-0002-0070-1320)
- Jing Ke (ORCID: https://orcid.org/0009-0008-1036-3864)
- Guanjun Chen (ORCID: https://orcid.org/0000-0002-8629-2168)
- Yifan Gong (ORCID: https://orcid.org/0000-0002-1930-443X)
- Ting-Ting Shi
- Yuan Wang (ORCID: https://orcid.org/0000-0001-7303-8219)
- Yan-Yan Ding (ORCID: https://orcid.org/0009-0002-4413-9197)
- Mengyu Zhao
- Chi Wang (ORCID: https://orcid.org/0000-0002-2550-2168)
- Juan Chen (ORCID: https://orcid.org/0000-0001-7515-5072)
- Song Zhang (ORCID: https://orcid.org/0000-0001-9815-7046)
- Lina Wang (ORCID: https://orcid.org/0009-0002-3877-4928)
- Jiafeng Xu (ORCID: https://orcid.org/0000-0003-1411-2153)
- Qian Yu (ORCID: https://orcid.org/0000-0002-2253-1449)
- Wuzhuang Tang (ORCID: https://orcid.org/0000-0001-5216-6596)
- Hong-Yan Cai (ORCID: https://orcid.org/0000-0003-3336-8808)
- Fangfang Ding
- Shi Feng (ORCID: https://orcid.org/0009-0009-5468-9791)
Institutions
- Anhui Medical University (CN)
- Hefei University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1016/j.phymed.2025.157061
- Citations
- 4
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 6.23