Acute Toxicity Study of Seed-Based Polymers in Wistar Rats: Evaluation of Safety Profile

Seed-based polymers are gaining attention in pharmaceutical formulations due to their biodegradable and biocompatible nature. The present study evaluates the acute toxicity profile of three different seed-based polymers in Wistar rats. Single oral doses (2000 mg/kg) were administered as per OECD guideline 423. The study recorded mortality, body weight changes, behavioral alterations, and biochemical parameters to assess any potential toxic effects. No mortality or significant behavioral changes were observed, confirming the safety of these polymers. Histopathological examination revealed no signs of toxicity, reinforcing their biocompatibility. The findings suggest the potential safe use of these polymers in drug delivery applications and highlight the need for further studies on their long-term safety.