Substantiation of manufacturing technology and clinical application of periodontal gel composition based on phytopreparation with antioxidant properties in the treatment of periodontal diseases in orthodontic patients

Actuality.In order to prepare patients with dentoalveolar anomalies (DA) against the background of gingivitis and periodontitis for active orthodontic treatment in order to reduce oxidative stress, it is advisable to use herbal remedies with antioxidant properties and 98. 2, 2025 . non-steroidal anti-inflammatory drugs that have anti-inflammatory, antimicrobial, analgesic, anti-edematous effects and accelerate reparative processes.The purpose is to develop and clinically test an extemporaneous periodontal gel composition based on a plant-derived flavonoid complex and benzydamine hydrochloride for the treatment of patients with malocclusion in the presence of gingivitis and generalized periodontitis before and during the active phase of orthodontic treatment.Material and methods.The development of the gel composition involved the creation of six batches containing different combinations of the intended main components.The optimum concentration of the gel-forming agent was selected experimentally.A comparative characterization of the number of components in these six series, depending on the concentration of the gelator, was carried out and the selection of active and auxiliary components of the gel composition was substantiated.The study examined 30 orthodontic patients aged 18 to 30 years with DA and periodontal tissue diseases, who were divided into two equal groups of 15 people.The main group received treatment with the developed gel composition, and the comparison group received a traditional treatment regimen.The observation periods using the OHI-S index, Mhlemann H.R. bleeding index and PMA were performed immediately after treatment in 5, 10 days and after one, six and 12 months of active orthodontic treatment with braces.Research results.After the experimental establishment of the final composition of the gel composition containing sodium alginate, nipagine, water for injection, benzydamine and comb drug based on flavonoids, its clinical testing was carried out.The analysis of the dynamics of the applied clinical and instrumental methods in patients of the main group who underwent treatment with the developed gel composition at different periods of observation showed better statistically significant values in contrast to those of the comparison group.Conclusion.The clinical results obtained allow us to characterize the gel composition proposed for the treatment of periodontal tissue diseases in orthodontic patients as a pathogenetically sound and highly effective agent that allows optimizing and accelerating healing processes, has intense anti-inflammatory properties and no side effects.