Correlation of Coronary Heart Disease Mortality with HALP Score: A Cross-Sectional Study Based on NHANES

This study investigates the association between HALP score (hemoglobin, albumin, lymphocytes, platelets) and all-cause mortality in coronary heart disease (CHD) patients using NHANES data (1998-2018). Eligible CHD patients were grouped into Q1-Q4 by HALP quartiles. Analyses included weighted Cox models, restricted cubic spline (RCS) regression, Kaplan-Meier (K-M) curves, and subgroup analyses. Results showed 937 all-cause deaths. After covariate adjustment, Q2-Q4 had lower mortality risk (HR=0.74, 0.68, 0.70; 95% CIs respectively). A significant J-shaped nonlinear relationship was found (nonlinear P<0.001) with a turning point at 78.02: each 1-unit increase in HALP ≤78.02 reduced death risk by 1.3% (HR=0.987), while the protective effect plateaued above this. K-M curves showed higher HALP correlated with higher survival, and subgroup analyses confirmed robustness. The HALP score exhibits a J-shaped relationship with all-cause mortality in patients with coronary heart disease (CHD) and has potential prognostic value.