Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis
This study reveals a GNAS-mediated mechanotransduction pathway that activates HSP90-dependent eNOS signaling to accelerate wound angiogenesis, suggesting novel targets for therapeutic intervention.
Authors
- Y. T. Zhang (ORCID: https://orcid.org/0009-0003-9000-5533)
- Zheng Guo (ORCID: https://orcid.org/0000-0002-2294-3873)
- Fuxin Ma (ORCID: https://orcid.org/0000-0001-5828-5238)
- Zhixiao Lin (ORCID: https://orcid.org/0000-0003-1472-7318)
- Li Tian (ORCID: https://orcid.org/0000-0002-6022-2137)
- Xueyong Li (ORCID: https://orcid.org/0000-0002-9022-5312)
- Yuchen Dong
- Jing Li (ORCID: https://orcid.org/0009-0000-3975-211X)
Institutions
- Tianjin Nankai Hospital (CN)
- Tang Du Hospital (CN)
- 303 Hospital of People's Liberation Army (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1016/j.jare.2025.07.041
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fourth Military Medical University
- Key Research and Development Projects of Shaanxi Province