RGS1 stabilized by METTL3-mediated m6A modification promotes the tumorigenicity and macrophage M2 polarization in osteosarcoma
METTL3 stabilized RGS1 mRNA in an m6A-dependent manner to promote the tumorigenicity and macrophage M2 polarization in osteosarcoma, suggesting a novel insight into the therapy of osteosarcoma.
Authors
- Zhizhong Liang
- Liqiang Zhang (ORCID: https://orcid.org/0009-0005-2873-0421)
- Mao Wang (ORCID: https://orcid.org/0000-0001-7583-1683)
- Yuxia Shi
Institutions
- Shanxi Provincial Cancer Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Journal of bone oncology
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1016/j.jbo.2025.100705
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00