Modified Saengmaeksan, an herbal formula containing six herbs, improves hypertension through RhoA/Rho kinase-mediated vasorelaxation
mSMS exhibits potent antihypertensive effects through the inhibition of the RhoA/Rho-kinase pathway, reduction of vascular remodeling, oxidative stress, and renal protection. These findings support the potential of mSMS as a novel therapeutic agent for hypertension, offering a multi-targeted approach with fewer side effects compared to conventional therapies. Further clinical studies are required to confirm its clinical efficacy.
Authors
- Hyo In Kim (ORCID: https://orcid.org/0000-0002-3916-6855)
- Hye-Lin Kim (ORCID: https://orcid.org/0009-0009-3528-9581)
- Sujin Shin (ORCID: https://orcid.org/0000-0001-5583-473X)
- Eun Sang Cho
- Changsop Yang (ORCID: https://orcid.org/0000-0003-1277-3329)
- Jin Ki Jung
- Sung Giu Jin (ORCID: https://orcid.org/0000-0003-1558-5155)
- Kyung Oh Jung (ORCID: https://orcid.org/0000-0002-5000-7791)
- Kyungjin Lee (ORCID: https://orcid.org/0000-0001-8590-9480)
- Young Mi Seok (ORCID: https://orcid.org/0000-0003-1273-3861)
- Doo Suk Lee (ORCID: https://orcid.org/0000-0003-3108-3577)
- Hyun Woo Kim (ORCID: https://orcid.org/0000-0003-2473-8360)
- Hyo Jung Kim (ORCID: https://orcid.org/0000-0002-1942-6779)
- Yohan Han (ORCID: https://orcid.org/0000-0001-8665-2306)
- Jinbong Park (ORCID: https://orcid.org/0000-0002-5984-5855)
- Hobin Moon (ORCID: https://orcid.org/0009-0006-7248-4325)
- Se-Jin Kim
- Huang Wei (ORCID: https://orcid.org/0000-0002-4395-167X)
- Hyun Hee Leem
Institutions
- Beth Israel Deaconess Medical Center (US)
- Dongguk University (KR)
- Kyung Hee University (KR)
- Korea Institute of Oriental Medicine (KR)
- Wonkwang University Hospital (KR)
- Research & Development Institute (US)
- Integrative Medicine Institute (US)
- National Development Institute of Korean Medicine (KR)
- Yeungnam University (KR)
- Chung-Ang University (KR)
- Wonkwang University (KR)
- Hainan Medical University (CN)
- Dankook University (KR)
Publication Details
- Journal
- Integrative Medicine Research
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1016/j.imr.2025.101207
- Citations
- 1
- Primary Topic
- Healthcare and Venom Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Chung-Ang University
- Ministry of Health and Welfare
- Korea Health Industry Development Institute