Promoting ferroptosis of keloid fibroblasts: a key mechanism underlying the efficacy of 5-aminolevulinic acid photodynamic therapy for keloids
ALA-PDT provides an effective and safe keloid treatment. Its mechanism involves inducing ferroptosis via ROS production and modulating the extracellular matrix to restore collagen balance. By selectively targeting KFs while sparing normal fibroblasts, ALA-PDT demonstrates remarkable therapeutic precision.
Authors
- Dongmei Shi (ORCID: https://orcid.org/0000-0002-0886-4191)
- Ning Zhang (ORCID: https://orcid.org/0000-0003-0909-6099)
- Dongmei Li (ORCID: https://orcid.org/0000-0002-4226-662X)
- Xiaoqing Wang (ORCID: https://orcid.org/0000-0002-2762-2497)
- Yahui Feng (ORCID: https://orcid.org/0009-0001-1636-7988)
- Jiaying Zhang (ORCID: https://orcid.org/0009-0000-9058-5265)
Institutions
- Weifang Medical University (CN)
- Georgetown University (US)
- Georgetown University Medical Center (US)
- Jining First People's Hospital (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1016/j.pdpdt.2025.104736
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00