Assessing the Relative Contribution of DSB Repair Proteins as a Function of LET
This research further highlights the importance of DSB repair pathways, particularly NHEJ, in determining cellular sensitivity to different radiation qualities, but suggests that in this system there is little difference in pathway dependence between X-rays and high-LET radiation. Mechanistic approaches like Medras offer a promising approach to predict radiation responses, to support more personalised and effective cancer treatments based on genetic profiles.
Authors
- Stephen J. McMahon (ORCID: https://orcid.org/0000-0001-5980-6728)
- François Chevalier (ORCID: https://orcid.org/0000-0002-8488-2324)
- Lydia L Gardner (ORCID: https://orcid.org/0009-0003-1544-910X)
- Kevin Tabury (ORCID: https://orcid.org/0000-0002-8004-3718)
- Francisco Liberal (ORCID: https://orcid.org/0000-0002-7917-8578)
- Jason Luke Parsons (ORCID: https://orcid.org/0000-0002-5052-1125)
- Shannon Thompson (ORCID: https://orcid.org/0000-0002-0051-1930)
Institutions
- Queen's University Belfast (GB)
- Centre National de la Recherche Scientifique (FR)
- École Nationale Supérieure d'Ingénieurs de Caen (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Normandie Université (FR)
- Belgian Nuclear Research Centre (BE)
- Centre de Recherche sur les Ions, les Matériaux et la Photonique (FR)
- University of Birmingham (GB)
Publication Details
- Journal
- International Journal of Particle Therapy
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1016/j.ijpt.2025.101198
- Citations
- 1
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- UK Research and Innovation