Atypical Neuropathic Symptoms Following Nexplanon: Possible Role of Edema-Induced Nerve Compression

Nexplanon is a subdermal contraceptive implant that is generally well tolerated; however, rare complications can occur. Although typical adverse events include localized pain and nerve irritation along specific dermatomes, diffuse neuropathic symptoms are uncommon. This case report suggests that subclinical edema-induced nerve compression, often accompanied by an inflammatory response, may contribute to such atypical presentations.