Prevalence and Phenotype of Transthyretin Val122Ile Variant in the Hispanic Community Health Study/Study of Latinos
The Val122Ile variant prevalence varied depending on AA proportions among H/Ls and was seen more commonly among Dominicans, highlighting opportunities for preventative hereditary transthyretin amyloid cardiomyopathy screening.
Authors
- Sanjiv J. Shah (ORCID: https://orcid.org/0000-0002-5655-8201)
- Humberto Parada (ORCID: https://orcid.org/0000-0001-6562-8577)
- Gregory A. Talavera (ORCID: https://orcid.org/0000-0001-5360-1107)
- Ambarish Pandey (ORCID: https://orcid.org/0000-0001-9651-3836)
- Tamar Sofer (ORCID: https://orcid.org/0000-0001-8520-8860)
- Carlos J. Rodríguez (ORCID: https://orcid.org/0000-0003-3618-9514)
- James M. Tauras
- Mayank Mohan Kansal (ORCID: https://orcid.org/0000-0003-2552-8744)
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Mathew S. Maurer (ORCID: https://orcid.org/0000-0001-5400-5008)
- Katrina Swett
- Bharat Thyagarajan (ORCID: https://orcid.org/0000-0001-6968-6985)
- Priscilla Duran Luciano (ORCID: https://orcid.org/0000-0003-4920-2941)
- Larissa Avilés‐Santa (ORCID: https://orcid.org/0000-0002-8130-0026)
- Martha L. Daviglus (ORCID: https://orcid.org/0000-0002-6791-8727)
- Barry E. Hurwitz
- Franklyn Gonzalez
Institutions
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- Cedars-Sinai Medical Center (US)
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- University of Minnesota (US)
- Beth Israel Deaconess Medical Center (US)
- Montefiore Medical Center (US)
- University of Miami (US)
- San Diego State University (US)
- University of Illinois Chicago (US)
- Southwestern Medical Center (US)
- National Institute on Minority Health and Health Disparities (US)
- Southwestern Medical Center (US)
- Columbia University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- JACC Advances
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1016/j.jacadv.2025.102034
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Miami
- University of North Carolina
- Northwestern University
- San Diego State University
- Albert Einstein College of Medicine, Yeshiva University
- University of North Carolina at Chapel Hill
- University of California, San Diego
- National Heart, Lung, and Blood Institute
- National Cancer Institute
- National Institute on Minority Health and Health Disparities