Histone H4 lysine 20 methylation marks genes dynamically regulated during erythroid maturation
There are dynamic changes in H4K20 methylation during cellular differentiation that correlate strongly with Pol II occupancy and activity. These changes occurred in genic regions, with H4K20me3 at the transcription start site correlated with Pol II pausing, and H4K20me1 gene body levels tightly linked with transcriptional changes. Together, these data provide important insights into the role of H4K20 methylation in the regulation of gene expression during cellular differentiation.
Authors
- Laurie A. Steiner (ORCID: https://orcid.org/0000-0002-2923-4105)
- Michael Bulger (ORCID: https://orcid.org/0000-0002-2010-9420)
- Kristin Murphy
- Zachary C. Murphy (ORCID: https://orcid.org/0000-0002-5181-5168)
- Xiurui Lv (ORCID: https://orcid.org/0000-0002-0118-2083)
- Michael Getman (ORCID: https://orcid.org/0000-0003-1669-4812)
- Nabil Rahman (ORCID: https://orcid.org/0000-0003-4627-6603)
- Deanna Abid
Institutions
- University of Rochester Medical Center (US)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s13072-025-00609-2
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases