Inhibition RIP1 prevents acute liver failure by suppressing hepatic apoptosis and attenuating the secretion of TNF-α from macrophages
Inhibition of RIP1 effectively alleviated LPS/GalN-induced ALF by reducing hepatic apoptosis and attenuating the secretion of TNF-α from macrophages, suggesting its potential as a therapeutic agent for ALF patients.
Authors
- Dahua Chen (ORCID: https://orcid.org/0000-0002-2122-9141)
- Aichun Li
- Jianwei Shen (ORCID: https://orcid.org/0000-0001-6779-6910)
Institutions
- Ningbo Medical Center Lihuili Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s40001-025-02948-y
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00