Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis
This study unveils an EV-driven mechanism of adipose tropism in ovarian cancer metastasis, where EVs promote the formation of senescent lipid-laden macrophages via CD36-mediated lipid uptake, remodeling the metastatic niche. Targeting CD36 and senescent cells offers a promising therapeutic strategy against omental metastasis.
Authors
- Wenhan Li (ORCID: https://orcid.org/0000-0002-9412-1166)
- Qiulei Wu (ORCID: https://orcid.org/0000-0002-6232-9528)
- Jing Cai (ORCID: https://orcid.org/0000-0002-0302-9998)
- Xiaoling Zhou (ORCID: https://orcid.org/0000-0001-6039-5540)
- Xiaoli Liu (ORCID: https://orcid.org/0000-0002-6204-4485)
- Lanqing Gong (ORCID: https://orcid.org/0000-0003-4183-9710)
- Guoqing Li (ORCID: https://orcid.org/0000-0002-6557-1301)
- Lin Huang (ORCID: https://orcid.org/0000-0002-4892-7871)
- Zehua Wang (ORCID: https://orcid.org/0000-0001-6423-8219)
- Ying Liu (ORCID: https://orcid.org/0000-0001-9385-992X)
- Xiangyu Xu (ORCID: https://orcid.org/0000-0001-6248-9268)
- Liqiong Cai (ORCID: https://orcid.org/0000-0001-6910-4586)
- Jing Zhao (ORCID: https://orcid.org/0000-0003-0764-8179)
- Linjuan Xu
Institutions
- Qingdao University (CN)
- Union Hospital (HK)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Qingdao Municipal Hospital (CN)
- Wuhan Union Hospital (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s12951-025-03612-7
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province