Jet lag-induced circadian disruption elevates glioma risk by altering molecular profiles in distinct brain regions
Chronic circadian disruption acts as a brain region-specific oncogenic stressor, driving transcriptional reprogramming of cancer pathways in a clock gene-dependent manner. Mechanistically, our study may establish a relationship of circadian dysfunction with glioma risk, underscoring the necessity for sex-stratified chronotherapeutic approaches in neuro-oncology.
Authors
- Yong Zhang (ORCID: https://orcid.org/0000-0001-5768-5395)
- Rufei Dai
- Jiawei Shen (ORCID: https://orcid.org/0000-0002-0393-8497)
- Zonghan Li (ORCID: https://orcid.org/0000-0003-0253-0139)
- Wanling Zheng
- Tianyi Ma (ORCID: https://orcid.org/0000-0001-5132-3756)
- Jichen Li (ORCID: https://orcid.org/0000-0003-0660-8888)
Institutions
- Xuzhou Medical College (CN)
- Fudan University (CN)
- Second Affiliated Hospital of Xuzhou Medical College (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1007/s12672-025-03253-0
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province