Deciphering hypoxia’s role in hepatocellular carcinoma prognosis with single-cell approaches
Key transcription factors like NOP58, MED8 play pivotal roles in hypoxia-induced HCC invasion and metastasis, and a predictive model based on these factors forecasts HCC survival. Our findings provide novel molecular markers and therapeutic targets for HCC, highlighting the importance of considering the hypoxia TME in diagnostic and treatment strategies.
Authors
- Di Chen (ORCID: https://orcid.org/0000-0002-6983-1641)
- Jun Liang (ORCID: https://orcid.org/0000-0001-7624-4413)
- Huiyu Liang
Institutions
- Community Health Center (US)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1007/s12672-025-03201-y
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94