Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle
Our findings establish large MAF transcription factors as key regulators of MYH4 expression and glycolytic metabolism in human skeletal muscle. This discovery provides novel insights into the evolutionary loss of type IIb myofibers in larger mammals and suggests potential strategies for enhancing muscle performance and mitigating fast-twitch fiber loss associated with aging and muscle degeneration.
Authors
- Ryo Fujita (ORCID: https://orcid.org/0000-0002-8392-0122)
- Andrey V. Zhelankin (ORCID: https://orcid.org/0000-0002-3014-2005)
- Satoru Takahashi (ORCID: https://orcid.org/0000-0002-0819-9478)
- Ekaterina A. Semenova (ORCID: https://orcid.org/0000-0003-1248-2855)
- Shunya Sadaki
- Hidetoshi Sakurai (ORCID: https://orcid.org/0000-0002-5383-9366)
- Ryosuke Tsuji
- Masafumi Muratani (ORCID: https://orcid.org/0000-0002-0276-8000)
- Edward V. Generozov (ORCID: https://orcid.org/0000-0002-6314-4883)
- Rinat Sultanov (ORCID: https://orcid.org/0000-0003-3918-708X)
- Ildus I. Ahmetov (ORCID: https://orcid.org/0000-0002-6335-4020)
- Koichi Ojima (ORCID: https://orcid.org/0000-0002-5973-1073)
- Iori Sakakibara (ORCID: https://orcid.org/0009-0000-8921-7748)
- Takuto Hayashi (ORCID: https://orcid.org/0009-0007-6313-4347)
- Takashi Kudo (ORCID: https://orcid.org/0000-0001-5477-7235)
- Gu Wenchao
- Masato Watanabe (ORCID: https://orcid.org/0000-0001-9442-2762)
- Ryoto Iwai
Institutions
- University of Tsukuba (JP)
- Inserm (FR)
- Chiba University (JP)
- Aichi Medical University (JP)
- Kazan State Medical University (RU)
- Université Paris-Est Créteil (FR)
- Kyoto University (JP)
- Institute of Livestock and Grassland Science (JP)
- Institut Mondor de Recherche Biomédicale (FR)
- Volga Region State Academy of Physical Culture, Sports and Tourism (RU)
- Liverpool John Moores University (GB)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s13395-025-00391-5
- Citations
- 5
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Japan Agency for Medical Research and Development
- Institut National de la Santé et de la Recherche Médicale
- Università degli Studi di Padova
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- University of Tsukuba
- Russian Science Foundation
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology