Ferulic acid suppresses Porphyromonas gingivalis biofilm formation via the inhibition of autoinducer-2 production and receptor activity
Although ferulic acid showed weak antibacterial activity against periodontopathogenic bacteria, it had low cytotoxicity and inhibited P. gingivalis biofilm formation. Ferulic acid inhibited AI-2 production and receptor activity, suggesting that ferulic acid is an efficient quorum-sensing inhibitor for controlling P. gingivalis biofilm formation.
Authors
- Koichi Tabeta (ORCID: https://orcid.org/0000-0002-7019-1872)
- Hnin Yu Lwin (ORCID: https://orcid.org/0000-0001-7871-751X)
- Yukari Aoki‐Nonaka (ORCID: https://orcid.org/0000-0002-4710-622X)
- Yoshihiro Minato
- Naoki Takahashi (ORCID: https://orcid.org/0000-0001-8952-7260)
- Daiki Ando
- Yuko Warita
- Aoi Matsugishi-Nasu
Institutions
- Niigata University Medical and Dental Hospital (JP)
- Niigata University (JP)
Publication Details
- Journal
- Archives of Oral Biology
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1016/j.archoralbio.2025.106365
- Citations
- 2
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- Japan Society for the Promotion of Science