Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort
Our study has identified several baseline metabolites and metabolic pathways associated with disease activity and response to different treatments in early RA. By integrating metabolomics and clinical data, we developed predictive models for response to treatment in early RA, though their predictive performance remains limited.
Authors
- Espen Andre Haavardsholm (ORCID: https://orcid.org/0000-0002-1427-4745)
- Ronald van Vollenhoven (ORCID: https://orcid.org/0000-0001-6438-8663)
- Gerður Gröndal (ORCID: https://orcid.org/0009-0009-6751-3330)
- Kristina Lend (ORCID: https://orcid.org/0000-0001-5037-5546)
- Till Uhlig (ORCID: https://orcid.org/0000-0002-6881-9552)
- Tahzeeb Fatima (ORCID: https://orcid.org/0000-0002-6082-2853)
- Georgios K. Vasileiadis (ORCID: https://orcid.org/0000-0003-0567-9190)
- Kim Hørslev‐Petersen (ORCID: https://orcid.org/0000-0002-5475-7610)
- Dan Nordström
- Cristina Maglio (ORCID: https://orcid.org/0000-0002-3786-5767)
- Björn Guðbjörnsson (ORCID: https://orcid.org/0000-0003-4631-6505)
- Merete Lund Hetland (ORCID: https://orcid.org/0000-0003-4229-6818)
- Tuulikki Sokka (ORCID: https://orcid.org/0000-0002-6972-5603)
- Michael Twahier Nurmohamed (ORCID: https://orcid.org/0000-0002-6274-1934)
- Jon Lampa (ORCID: https://orcid.org/0000-0002-7856-3968)
- Anna Rudin (ORCID: https://orcid.org/0000-0002-4137-1276)
- Araz Rawshani (ORCID: https://orcid.org/0000-0003-2066-3533)
- Marte Schrumpf Heiberg (ORCID: https://orcid.org/0000-0003-1104-7755)
- Yuan Zhang (ORCID: https://orcid.org/0000-0001-9747-1391)
- Mikkel Østergaard
Institutions
- Reykjavík University (IS)
- University of Copenhagen (DK)
- Karolinska University Hospital (SE)
- University of Helsinki (FI)
- University of Iceland (IS)
- University of Southern Denmark (DK)
- University of Oslo (NO)
- Helsinki University Hospital (FI)
- Sahlgrenska University Hospital (SE)
- Glostrup Hospital (DK)
- Rigshospitalet (DK)
- Karolinska Institutet (SE)
- Reade (NL)
- National University Hospital of Iceland (IS)
- Diakonhjemmet Hospital (NO)
- Central Finland Health Care District (FI)
- Amsterdam University Medical Centers (NL)
- Hospital District of Helsinki and Uusimaa (FI)
- University of Gothenburg (SE)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s13075-025-03616-6
- Citations
- 4
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Göteborgs Universitet