Ulinastatin inhibits macrophage M1 polarization to improve acute pancreatitis-associated intestinal barrier dysfunction by promoting Nrf2 signaling pathway activation
Ulinastatin protected against both AP and the associated intestinal barrier dysfunction. It suppressed the inflammatory response and oxidative stress by promoting Nrf2 nuclear translocation and inhibiting M1 macrophage polarization through the activation of the Nrf2 signaling pathway.
Authors
- Jiahui Fang
- Ming Gao (ORCID: https://orcid.org/0000-0003-1626-4580)
- Qi Wang (ORCID: https://orcid.org/0000-0001-7626-676X)
- Siqi Zhang (ORCID: https://orcid.org/0009-0009-0610-8809)
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s40001-025-02952-2
- Citations
- 1
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Anhui Medical University