Coordinated gene expression within sustained STAT3‐associated chromatin conformations contributes to hepatocellular carcinoma progression
Sustained p-STAT3 activation significantly alters the 3D chromatin conformation in HCC, particularly through the formation of FIREs. These p-STAT3-associated FIREs drive the expression of genes involved in HCC aggressiveness and remain active despite STAT3-targeted treatments, suggesting a mechanism of drug resistance. These findings highlight the potential of targeting 3D chromatin dynamics as a therapeutic strategy in HCC, especially in cases of STAT3 inhibitor resistance.
Authors
- Sung-Won Yoon
- Nuri Choi (ORCID: https://orcid.org/0000-0002-5526-5124)
- Daeyoup Lee (ORCID: https://orcid.org/0000-0003-2006-1823)
- Kyung Hyun Yoo (ORCID: https://orcid.org/0000-0003-2172-5564)
- Hyoung‐Pyo Kim (ORCID: https://orcid.org/0000-0003-1441-8822)
- Sunyoung Jang (ORCID: https://orcid.org/0000-0001-8978-7951)
- Jong Hoon Park (ORCID: https://orcid.org/0000-0002-8082-0214)
- Lark Kyun Kim (ORCID: https://orcid.org/0000-0001-5983-4470)
- Hyeok-Jun Yang (ORCID: https://orcid.org/0000-0003-0152-8520)
- Su-hyang Han
Institutions
- Korea Advanced Institute of Science and Technology (KR)
- Yonsei University (KR)
- Severance Hospital (KR)
- Sookmyung Women's University (KR)
- Gangnam Severance Hospital (KR)
Publication Details
- Journal
- Cancer Communications
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1002/cac2.70049
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Korea Basic Science Institute
- National Research Foundation of Korea