HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana
HIV drug resistance (HIVDR) was retrospectively characterized among 20 children and adolescents with HIV with virologic failure on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy, and virologic response in those switched to dolutegravir (DTG)-based therapy described. All participants had at least one NNRTI resistance mutation, most commonly K103N (N = 12) and 15 (75%) had nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations, most commonly M184I/V (N = 15). Five (45%) of 11 participants who were switched to DTG-based regimens for a median of 50 months had HIV suppression. Further studies to understand the role of pre-existing HIVDR in the failure of DTG-based regimens are needed.
Authors
- Kwamena William Coleman Sagoe (ORCID: https://orcid.org/0000-0002-8891-8267)
- Bamenla Q. Goka (ORCID: https://orcid.org/0000-0003-2324-3980)
- Joel Hague (ORCID: https://orcid.org/0000-0003-4687-6756)
- Joycelyn Assimeng Dame (ORCID: https://orcid.org/0000-0002-5197-023X)
- Awewura Kwara (ORCID: https://orcid.org/0000-0002-1118-8331)
- Yakubu Alhassan (ORCID: https://orcid.org/0000-0002-0658-3820)
- Charles Martyn‐Dickens (ORCID: https://orcid.org/0000-0002-6659-9111)
- Kwasi Torpey (ORCID: https://orcid.org/0000-0003-1628-2922)
- Rami Kantor
- Margaret Lartey
- Vlad Novitsky
- Adwoa K. A. Afrane
Institutions
- University of Ghana (GH)
- Brown University (US)
- Komfo Anokye Teaching Hospital (GH)
- Korle Bu Teaching Hospital (GH)
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- AIDS Research and Therapy
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s12981-025-00762-4
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fogarty International Center