Comprehensive Insights into APOBEC Mutations in Thyroid Cancer: Prognostic and Therapeutic Discoveries
Our study systematically characterizes APOBEC mutations across various cancer types and underscores their promise as biomarkers for aggressive tumor phenotypes, prognostic assessment, and immunotherapy response to THCA. These findings were accomplished through multi-omics sequencing and validated through comprehensive in vitro and in vivo experiments.
Authors
- Yuqi Wang (ORCID: https://orcid.org/0000-0001-8510-4949)
- Yanchao Qin
- Xianhui Ruan (ORCID: https://orcid.org/0000-0003-3049-7532)
- Mengyu Li
- Jialong Yu
- Yiping Zou (ORCID: https://orcid.org/0000-0002-8945-6244)
- Xuan Cheng (ORCID: https://orcid.org/0000-0002-7382-0240)
- Yu Liu (ORCID: https://orcid.org/0000-0002-6709-8589)
- Wei Luo (ORCID: https://orcid.org/0000-0003-2660-7065)
- Chao Yang (ORCID: https://orcid.org/0000-0001-9276-5673)
- Feng Liu (ORCID: https://orcid.org/0000-0002-1074-2601)
- Mei Tao
- Yue Huang (ORCID: https://orcid.org/0009-0006-9557-450X)
- Ziyun Liu (ORCID: https://orcid.org/0000-0003-2992-7590)
- Xiaobin Shang (ORCID: https://orcid.org/0000-0002-7155-9499)
- Xiangqian Zheng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Shanxi Provincial Cancer Hospital (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
Publication Details
- Journal
- Biological Procedures Online
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s12575-025-00288-z
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Tianjin Medical University
- Tianjin Science and Technology Program