C18:0 GM3 ganglioside’s efficacy in LPS-induced parkinsonism: neuroprotection, inflammatory inhibition and gliosis mitigation
Our data indicate that C18:0 GM3 primarily attenuates the TLR4-driven inflammatory cascade initiated by intrastriatal LPS, thereby secondarily preserving striatal dopaminergic terminals and improving motor deficits. Although these results highlight anti-inflammatory neuroprotection, additional studies are required to determine whether GM3 also modulates downstream Parkinson-specific processes such as α-synuclein aggregation or progressive neurodegeneration.
Authors
- Jui‐Hu Shih (ORCID: https://orcid.org/0000-0001-7884-1246)
- Cheng‐Tsung Liu (ORCID: https://orcid.org/0000-0002-5014-0349)
- I‐Hsun Li (ORCID: https://orcid.org/0000-0002-2824-4774)
- Tsung–Ta Liu (ORCID: https://orcid.org/0000-0002-8865-0272)
- Hao-Yuan Hung (ORCID: https://orcid.org/0000-0001-6455-3032)
- Ta-Kai Chou
- T.C. Wang (ORCID: https://orcid.org/0009-0003-7701-1234)
- Sheng‐Shian Li (ORCID: https://orcid.org/0000-0003-4727-8870)
- Yu-Chieh Chu
- Chuang-Hsin Chiu
Institutions
- Tri-Service General Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Behavioral and Brain Functions
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s12993-025-00289-8
- Citations
- 2
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Defense Medical College
- Tri-Service General Hospital
- National Science and Technology Council