Electrochemical Ni-Catalyzed α-Selective Hydrocarboxylation of Styrenes with CO<sub>2</sub>
Herein, an α-selective electrocarboxylation of styrene enabled by Ni-H utilizing water as the hydride source under a CO<sub>2</sub> atmosphere is described. This approach features high regioselectivity and good functional-group compatibility. A series of anti-inflammatory drug molecules (ibuprofen, naproxen, flurbiprofen, and fenoprofen) were obtained in a direct and rapid way. Moreover, mechanistic studies have been conducted and provide support for the proposed mechanism.
Authors
- Youai Qiu (ORCID: https://orcid.org/0000-0002-5859-6754)
- Yanwei Wang (ORCID: https://orcid.org/0000-0001-6042-3206)
- Weikang Qi
Institutions
- Nankai University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1021/acs.orglett.5c02243
- Citations
- 3
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 2.11
Funders
- National Natural Science Foundation of China
- Nankai University
- State Key Laboratory of Coordination Chemistry
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities