The practical use of a new preparation of botulinum toxin type A in the treatment of hypertonus of the masticatory and mimic muscles, pain and autonomic nervous system disorders

The emergence of new botulinum toxin type A (BTA) drugs requires the study of their efficacy and safety in various neurological diseases in order to find the most effective and safe drugs. This article presents clinical cases using the new drug NOVACUTAN-BTA. It has been shown to be effective and safe not only in correcting expression lines, but also in treating neurological conditions such as bruxism, blepharospasm, facial nerve neuropathy and hemifacial spasm, autonomic disorders and pain syndromes. Its unique formulation using a new proprietary strain (CBAT-4), the highest purification rate (98.99 % compared to 95 % for Onabotulotoxin), the use of lyophilization which preserves the activity of the drug, as well as its favourable clinical profile, high treatment response rate, long duration of effect achieved, all combine to differentiate NOVACUTAN- BTA from other currently approved BTA drugs.

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Medical alphabet
Published
2025-07-26
DOI
https://doi.org/10.33667/2078-5631-2025-15-14-20
Primary Topic
Botulinum Toxin and Related Neurological Disorders
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article
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article

The practical use of a new preparation of botulinum toxin type A in the treatment of hypertonus of the masticatory and mimic muscles, pain and autonomic nervous system disorders

Olga Orlova, P. N. Iakovleva, Л. Р. Мингазова, А. С. Орлова et al.
Medical alphabet
Botulinum Toxin and Related Neurological Disorders
article

The practical use of a new preparation of botulinum toxin type A in the treatment of hypertonus of the masticatory and mimic muscles, pain and autonomic nervous system disorders

Olga Orlova, P. N. Iakovleva, Л. Р. Мингазова, А. С. Орлова, Diana Krasavina, O. V. Mizurova, V. Yu. Avtomonov, Zh. A. Gorodnicheva
article en

Abstract

The emergence of new botulinum toxin type A (BTA) drugs requires the study of their efficacy and safety in various neurological diseases in order to find the most effective and safe drugs. This article presents clinical cases using the new drug NOVACUTAN-BTA. It has been shown to be effective and safe not only in correcting expression lines, but also in treating neurological conditions such as bruxism, blepharospasm, facial nerve neuropathy and hemifacial spasm, autonomic disorders and pain syndromes. Its unique formulation using a new proprietary strain (CBAT-4), the highest purification rate (98.99 % compared to 95 % for Onabotulotoxin), the use of lyophilization which preserves the activity of the drug, as well as its favourable clinical profile, high treatment response rate, long duration of effect achieved, all combine to differentiate NOVACUTAN- BTA from other currently approved BTA drugs.

Medical alphabet(15)
Sechenov University (RU), Central Research Institute (IN), Aesthetic Surgery Center (US), Science Club (US), Saint Petersburg State Pediatric Medical University (RU)
Openalex Percentile: Top 72%
Botulinum Toxin and Related Neurological Disorders
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The practical use of a new preparation of botulinum toxin type A in the treatment of hypertonus of the masticatory and mimic muscles, pain and autonomic nervous system disorders — Olga Orlova, P. N. Iakovleva, et al. · Medical alphabet (2025) | TGRS Research Map | TGRS