Dual Photoredox/Ni-Catalyzed Decarboxylative Coupling of α-Amino Acids to Uridine Derivatives
We present visible-light-mediated decarboxylative coupling of <i>N</i>-substituted glycine derivatives to the <i>N</i>3-position of <i>N</i>5-halo-uridine. The process utilizes dual iridium or organic dye and nickel catalysis to yield <i>N</i>3-amino methylene uridine derivatives. This work represents a new methodology to functionalize uridine derivatives as shown by 20 examples including biotin, fatty acid, and fluorinated residues among others.
Authors
- Anna M. Rydzik (ORCID: https://orcid.org/0000-0003-3158-0493)
- Werngard Czechtizky (ORCID: https://orcid.org/0000-0003-4487-2399)
- Marion Garreau (ORCID: https://orcid.org/0000-0002-4514-5751)
- Enqin Fu
- Carlo Cassani
- Christian Oettinger
Institutions
- AstraZeneca (South Korea) (KR)
- Pharmaron (United Kingdom) (GB)
- AstraZeneca (Australia) (AU)
- AstraZeneca (Netherlands) (NL)
- AstraZeneca (Switzerland) (CH)
- Institute of Immunology (HR)
- AstraZeneca (Finland) (FI)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1021/acs.orglett.5c02253
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00