Letrozole in Treating Polycystic Ovary Syndrome-Associated Infertility

Letrozole was originally reported for the treatment of breast malignancy, however, it exhibited potential in treating infertility disorders linked with polycystic ovary syndrome (PCOS). The purpose of this research was to investigate the usefulness of letrozole in treating infertile females with PCOS. A randomized, prospective, clinical trial involving 105 females aged between 19 and 33 was performed. Over a couple of months, evaluations were completed on days two and twelve of the females who received letrozole tablets. Substantial statistical ovulatory increment, more endometrial thickness, and altered hormone levels were identified. These changes signify letrozole's potential as a useful choice for PCOS-associated infertility. To fully comprehend its therapeutic potential and optimize treatment regimens, additional future study is required.

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Publication Details

Journal
Kerbala journal of pharmaceutical sciences.
Published
2025-06-30
DOI
https://doi.org/10.62472/kjps.v16.i26.48-63
Primary Topic
Ovarian function and disorders
Type
article
Field-Weighted Citation Impact
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article

Letrozole in Treating Polycystic Ovary Syndrome-Associated Infertility

Amal Umran Mosa, Hameedah Hadi Abdulwahid, Rihab kadhim
1 links
Kerbala journal of pharmaceutical sciences.
Ovarian function and disorders
article

Letrozole in Treating Polycystic Ovary Syndrome-Associated Infertility

Amal Umran Mosa, Hameedah Hadi Abdulwahid, Rihab kadhim
article en

Abstract

Letrozole was originally reported for the treatment of breast malignancy, however, it exhibited potential in treating infertility disorders linked with polycystic ovary syndrome (PCOS). The purpose of this research was to investigate the usefulness of letrozole in treating infertile females with PCOS. A randomized, prospective, clinical trial involving 105 females aged between 19 and 33 was performed. Over a couple of months, evaluations were completed on days two and twelve of the females who received letrozole tablets. Substantial statistical ovulatory increment, more endometrial thickness, and altered hormone levels were identified. These changes signify letrozole's potential as a useful choice for PCOS-associated infertility. To fully comprehend its therapeutic potential and optimize treatment regimens, additional future study is required.

Kerbala journal of pharmaceutical sciences.Vol. 16(26)
Gynecologic Oncology Group (US), University of Kerbala (IQ)
Openalex Percentile: Top 75%
Ovarian function and disorders
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