Effect of impaired sensitivity to thyroid hormones on the risk of insulin resistance and dyslipidemia in polycystic ovary syndrome patients

This study assessed thyroid hormone sensitivity indices (THSI) and their impact on insulin resistance (IR) and dyslipidemia risk in euthyroid individuals with polycystic ovary syndrome (PCOS).A retrospective analysis of 226 PCOS patients and 189 healthy euthyroid controls was conducted. Demographic, metabolic, and thyroid function data were collected. Spearman correlation was utilized to assess relationships with THSI and metabolic parameters. The risk of IR and dyslipidemia in relation to THSI was assessed through logistic regression analysis. PCOS patients demonstrated significantly elevated levels of certain THSI, including the FT3/FT4 ratio and TFQI_FT3. The risk of IR was found to be increased in relation to higher quartiles of TSHI, TT3RI, TT4RI, TFQI_FT3, and TFQI_FT4. When controlled for age, BMI, and dyslipidemia, the TFQI_FT4-Q4 group exhibited a threefold higher risk of IR relative to the TFQI_FT4-Q1 group (OR = 3.00; 95% CI: 1.04, 8.64). The elevated risk of dyslipidemia was linked to higher quartiles of TFQI_FT3 (OR = 3.04; 95% CI: 1.13, 8.19). PCOS individuals with IR or dyslipidemia exhibit impaired central thyroid hormone sensitivity. Furthermore, a heightened susceptibility of IR and dyslipidemia is strongly correlated with impaired central thyroid hormone sensitivity among PCOS individuals.